A good place to start your visit to Hannibal Missouri, is at the Mark Twain Memorial Shrine. Inside the shrine is the two room house Mark Twain was born in. Clara, the only child of Clemens to outlive him approved of the design from architectural drawings. She said it was like her father. . . unusual, different and ahead of its time. Looking at it from the bridge on Highway 107 going north, the top looks like a large ship.